Total-body PET is the latest technological advancement in medical imaging for the discovery, monitoring and treatment of diseases.

Total-body PET has been hailed as transformational by medical and scientific communities, providing a highly sensitive view of the entire body in near real-time.

With higher sensitivity than existing technology, NPIP’s total-body PET scanners will provide new insights into biology that  have never been seen before, improving our detection, diagnosis and treatment of complex, multi-organ diseases.

Supplied by Siemens Healthineers, the two Biograph Vision Quadra PET/CT scanners are equipped with technical precision that redefines the boundaries of molecular imaging and enables outstanding image clarity of a patient’s entire body in near real-time.

Current PET technology is less sensitive and requires the patient to be repositioned multiple times to achieve a full–body field of view. This only provides researchers with part of the picture because large sections of the body are not in the field of view. This limits application to localised regions of the body or single organs of interest, such as the heart, brain, or specific tumours.

The advancement of total-body PET will overcome many of the existing barriers that have so far limited its use to elevate PET innovation and translation to the next level.

Benefits of total-body PET

Multiplexing

Multiplexing is a technique that allows for the simultaneous imaging of multiple biological processes using different radiotracers. This is achieved by using radiotracers that emit photons of different energies, which can then be distinguished by the PET scanner. This allows for the creation of separate images for each radiotracer, and simultaneous imaging of multiple biological systems providing a comprehensive understanding of the body’s physiology.

Single Scan Efficiency

Total-body PET scanning offers a notable improvement in scan capacity and sensitivity compared to the conventional PET imaging, using a series of bed positions. A single total-body PET scan can comprehensively acquire data from the entire body during a single session in near-real time, leading to substantial reductions in both time and resource consumption that would otherwise be expended on multiple scans.

Accurate Staging and Assessment

Total-body PET plays a pivotal role in enhancing the precision of disease staging and evaluation by affording a comprehensive perspective on intricate disease advancement. This advanced imaging technique enables medical practitioners to more effectively gauge the full scope of disease progression, encompassing conditions that affect multiple organ systems, such as cancer and inflammatory diseases.

Monitoring Treatment Progress

Total-body PET extrapolates a more physiological characterisation means of tracking the response to treatment across the entirety of the body. This enables doctors to evaluate the efficacy of treatments comprehensively and at an early timepoint and make requisite adaptations as needed.

Research and Personalisation

Total-body PET holds significant promise in the realm of scientific research for the advancement of predictive therapeutic indices and precision medicine. Its applications extend to drug development research, encompassing the monitoring of pharmacokinetics and pharmacodynamic properties of medications. Furthermore, total-body PET contributes to the development of personalised medicine paradigms, allowing treatments to be finely tailored based on individual patient conditions.

Early Diagnosis

The capacity to conduct whole-body scans has the potential to expedite the early detection of diseases, including cancers, heart disease, and neurological disorders, prior to the onset of symptoms or extensive progression.

Total-body PET imaging is revolutionising medical imaging, providing a more complete picture of health for patients.

A total-body PET scan is a medical imaging technique that uses a small amount of radioactive material and a special camera to create detailed images of the inside of the body. A patient is injected with a small amount of radioactive tracer. The PET scanner then detects the gamma-ray emissions produced by the tracer as it accumulates in different parts of the body.

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